In the beginning, Mr. Incredible is tricked into helping Syndrome develop his killer robot by fighting it on a deserted island. Now, the island's name is mentioned only one time, by an autopilot program which pronounces it "Noh-mah-nisan." Which, yeah, sounds vaguely Pacific-island-y, so almost no one gave it a second thought. But the name is in fact spelled "Nomanisan." As in "No Man Is An," as in "No Man Is An Island," as in "This wasn't the deal, Hollywood! We don't watch movies to learn about the writings of 17th-century poet John Donne!"
Donne first coined the phrase "No man is an island" in 1624 to explain his idea that humans are their best selves when they work together and depend on each other, because we are all the same noble creatures endowed with the spark of the divine. Four centuries later, Pixar ignored the existence of internet comment sections and embraced that notion by turning it into a heartfelt message about the importance of family, all hinted at through some very clever wordplay. Then, for whatever reason, they slightly Ayn-Rand-ed the whole thing by adding in stuff about how us puntermensch should submit to a race of natural-born superhumans. Hey, at least we'll have that nice pun to remember when the Incredible family forces us to go into hiding beneath the earth when they eventually turn on humanity. So it's not gonna be all bad, right?