Traces of drugs can be present in spit, blood, and even hair follicles, but few studies have delved into how much they can accumulate inside that special fluid. It turns out that it can be enough to trigger a serious allergic reaction. Unfortunately for the annals of science, the understandably embarrassed woman skipped out on a follow-up appointment, which prevented doctors from confirming their suspicions that this may be the first confirmed case of its kind.
Related: 17 Horrifying Ways Sex Can Go Terribly Wrong
Men Can Be Allergic To Their Own Sperm
Thankfully, sperm allergy, a.k.a. seminal plasma hypersensitivity, is fairly rare, affecting between 20,000 and 40,000 people in the United States. But while the allergy mostly affects women (for whom handling sperm is pretty much always optional), sometimes men themselves can have it too. And the very few who suffer from it really suffer. Any skin that comes contact with ejaculate can experience swelling (bad timing), redness, itching, and a severe burning sensation. And some unlucky clumsy ejaculators may also get hives, difficulty breathing, and even anaphylaxis.
But many don't even need to make a mess all over themselves to experience the grave consequences. In a study conducted by Marcel Waldinger, a professor of sexual psychopharmacology (hands-down the university department with the best office parties) at Utrecht University, they observed that a whopping 88% of sperm-allergic male subjects also had an autoimmune response when no splashback occurred. The moment their sperm leaves the testicles, these men start getting postorgasmic illness syndrome, or POIS, and feel flu-like symptoms such as fatigue, sore throat, headache, fever, mood changes, and even memory or concentration problems (instead of just pretending to have all that stuff to get out of the awkward morning-after breakfast).