So let's take the adventure and tropes of the Indiana Jones franchise and set it all in the middle of World War II, with a massive battle acting as the backdrop, like the Battle of Guadalcanal, Midway, or Stalingrad. Better idea: Set it in the Battle of Berlin and have it be the last Indiana Jones/Nazis story ever. World War II already makes the quest for the magical artifact important (who knows what the Nazis could do with its power?), so take that same set of dramatic stakes and add another: Indy is surrounded by fellow soldiers and/or innocent civilians whose lives will be directly affected by whether he succeeds in his quest. If the Nazis somehow successfully wielded the powers of the Ark of the Covenant, we would never have seen their effortless global takeover on screen. Put the quest for the Ark in the middle of a big battle, and the life of every Allied soldier in that battle is directly at stake.
There's even in-canon precedent for this kind of Indy adventure. In Kingdom of the Crystal Skull, we learn that once the U.S. entered World War II, Indy became an Army intelligence agent and was eventually decorated with a ton of medals. He served in the Pacific Theater. He was a double agent in Berlin. Indiana Jones was a secret agent who infiltrated the Nazis! He was the American James Bond, which is what George Lucas wanted him to be to begin with. Why can't we see some of that happen?