The star of Mr. Smith was an orangutan named Cha Cha who was captured and taken to a government research center in Washington, D.C., where he drank an experimental mixture intended to increase human intelligence. This mixture gave Cha Cha an IQ of 256 and the ability to speak. Naturally, they immediately made him a political adviser. Get it? A monkey could do a politician's job!
You'd think that a talking orangutan would be one of the biggest scientist discoveries of all time, even in a sitcom world based around a joke your grandma would tell at Thanksgiving dinner (and get her booed away from the table for her trouble). But no, the entire premise is truly about the wacky shenanigans of a superintelligent primate in the world of politics.
"I tried to present my cure for cancer, but the Senate filibustered it."
But they couldn't even be bothered to keep to basic satire: Cha Cha had a brother named Bobo who also escaped during the accident, so the show would often neglect its own barely existent plot to focus instead on the superintelligent Cha Cha keeping his still-primitive sibling out of trouble. Other wacky antics included various guest stars almost finding out that Mr. Smith was a talking monkey, and what happens when a talking monkey falls in love with a regular monkey. So they went into the show with two subjects -- "monkeys" and "politics" -- and it turns out that all they could handle was "monkeys."