Even if there's an asthmatic 12-year-old under that armor, we're still scared shitless.
Once the numbers became too much for even the Hospitallers to handle, they high-tailed it to Cyprus. They were there for about 20 years until they realized that dicking around in Cyprus involved way less killing than they were used to, and took the island of Rhodes from whatever poor fool was controlling it.
While in Rhodes, the Knights fought off invasions from both the Sultan of Egypt in 1444 and from the Ottoman Empire in 1480 (the latter was coming off their own conquest of Constantinople, the single most difficult-to-invade city on the planet.).
Finally the knights' reign ended, when the aptly-named Ottoman Suleiman the Magnificent invaded the island with nothing less than 200,000 troops. Despite the fact that the knights only had 7,000 men to defend their holdings, it still took six freaking months for Rhodes to fall.
The knights abandoned Rhodes and moved to Malta and, sure enough, the Turks sent another massive army to besiege it. Historians rank the Siege of Malta as one of the most epic, transformative moments in military history, pretty much the Citizen Kane of sieges. It was one of the most celebrated events in its time, known throughout the corners of Christendom.
Why? Because the knights managed to fight off a massive horde of nearly 50,000 Turks with a few thousand men and absolutely zero room to retreat.
The Turks had lots of room to retreat, however, and after four months of watching the knights laugh off the 130,000 cannon balls they fired at them, the Turks turned and ran. It was the first time they had been beaten in 100 damned years.