Ignatius of Loyola was Cannon-Proof
Living in the early 1500s, Ignatius spent a good chunk of his life as a military man. A gambling, barroom brawlings military man. Oh, did we mention the whoring? Or as he put it in his autobiography "wenching."
During a huge battle with the French, his own men knew they were doomed and proposed a surrender. Ignatius would have none of that shit. He fought on and, shortly thereafter, he was shot with a friggin' cannon.
The ball passed right between his legs, tearing one open and smashing the shin in his other leg. When he was carried to town to be treated, his broken leg had to be set, rebroken then set again. A chunk of bone sticking out had to be sawed off. When it was discovered that whoever set his leg had fucked it up so bad it was now shorter than the other one, they used weights to try to unsuccessfully stretch it out.
"Boy, we are just not good doctors."
When you consider this was around 1520 and they didn't have frivolous luxuries like sterilization and anesthesia, you realize the guy was more hard-core than entire countries' worth of today's pansies.