About the one thing she has in common with the original Doctor Poison is the "creepy" part. In the early Wonder Woman comics, Doctor Poison was a Japanese princess who posed as a man to help the Nazis win World War II with her near-magical potions. She was only revealed to be Japanese royalty near the end of her first appearance, probably as the creators realized they hadn't filled the issue's obligatory anti-Asian racism quota.
Her potions are also much wackier than the chemical weapons seen in the movie. Her most famous one is the "Reverso" formula, which makes people do the opposite of what they're told (it's also known as "being a teenager"). The idea is that the American generals will be like "Hey fellas, let's go win the war," but the soldiers will go and do the opposite, dooming the country. The formula has unexpectedly sexy effects on the troops:
In the end, Doctor Poison's femininity is her undoing -- Wonder Woman says she realized she must be a lady in disguise because of her "delicate hands."
The fearsome Doctor Poison is eventually overtaken by Wonder Woman's dangerously sugar-addicted sidekick, Etta Candy, whose main purpose in the comic was serving as a vehicle for insensitive weight jokes.
In her next appearance, Poison poses as a Chinese nightclub dancer and easily fools Wonder Woman's pilot pal Steve Trevor, even though he'd met her before, because all of the billions of people in Asia look the same to him (racism quota: met).
This time, Doctor Poison's new formula is a gas that stops the engines of all the planes in America, which is really stretching the definition of "poison." Years later, it's revealed that this criminal genius accidentally killed herself by drinking some "Reverso" and turning into a fetus. We're not sure why a chemical that makes people do the opposite of what they're told would cause reverse aging, so we're guessing someone told her "Hey, don't turn into a fetus" and she went and did that.