Doctors actually warn that wearing tight pants like skinny jeans can compress the lateral femoral cutaneous nerve, which runs down your thigh and, like all other nerves, is there to register physical sensations like touch and pain.
"Even if I wear them ironically?
Therefore, if you squeeze your legs into a tight denim casing like some sort of hairy, flesh-colored sausage, the constant pressure on the LFC nerve might cause it to go into overdrive and start registering pain like crazy before ultimately crashing and burning. The medical name for it is meralgia paraesthetica. Despite sounding like a supporting villain in a Harry Potter book, that's actually a serious neurological disorder that causes numbness of the leg, stinging pain, oversensitivity to heat and even atrophied leg tissue in some cases.
Leg tissue if you're lucky.