Isn't he notable because he appears twice? Well, not really. He's not the only Holmes villain to make a repeat appearance. And even then, he never has a relationship with Holmes per se. Sure, he wants Holmes dead, but that's because Holmes is all up in his s**t, not because he's playing a vendetta-driven cat-and-mouse game. He's just a normal crime lord with a normal crime lord aversion to detectives sniffing around his operation. His motivation isn't shenanigans; it's cold hard cash.
That's also why when the time comes to have Holmes killed, he doesn't use bombs, an electric chair, or poisoned shoes. He simply tells his men to beat Holmes to death in the street or to run his brainiac ass over with a horse-drawn carriage. As for face-to-face encounters, they only meet once ... and that meeting ends with them plunging over a waterfall, not exchanging witty banter.