It's a minimalist masterpiece that would've been well-received had it been made for the high art crowd. "Loss," however, was not that. It was coming from Ctrl+Alt+Del, a webcomic about two guys who sit on a couch making jokes about video games. To say that the strip broke the comic's fanbase would be a massive understatement. The average Ctrl+Alt+Del update traditionally revolved around irreverent snark, mindless violence, surrealistic nonsense, and jokes about how girls who play video games are nigh-on mythical creatures. So "Loss" was the artistic equivalent of, well ... a miscarriage storyline in a joke-a-day gaming webcomic.
Bewildered, baffled, and bwhat-the-fucked-out, people responded in the only way that made sense: by memeing the living hell out of "Loss." And they (and the wider internet) have kept doing it for the last ten goddamn years, in increasingly abstract ways.