Since caving half your face in isn't enough (obviously), Parry-Romberg syndrome also discolors the skin, sinks your eyeball back into your skull, and causes your jaw to stop opening properly. And some unlucky bastards experience additional side effects like migraines, seizures, and muscle spasms in the "lucky" half of their face. And we probably shouldn't have called them bastards just now, since it typically strikes teenage girls right in time for senior prom.
If the thing that disturbs you the most about Parry-Romberg syndrome is its asymmetricalness, then allow us to show you lipodystrophy. Lipodystrophy translates to "fat loss," which you'd normally think of as a good thing -- right up until you lose all of it. See, a nice layer of fat is what gives your face everything that makes it recognizable -- like cheeks, lips, and the lack of a tendency to cause neighborhood children to awaken in the middle of the night swimming in pools of terror pee.
Viegas, Diniz, et al.
"See you tonight, Li'l Jimmy!"
Lipodystrophy is a common side effect of powerful antiretroviral drugs, meaning that even after you've contracted HIV, the universe still isn't quite finished kicking you in the dick. Don't think you're safe from this condition by avoiding HIV, however: There are dozens of factors -- ranging from environmental triggers to your own sad, broken genes -- that could cause you to transmogrify into Skeletor without warning. On a related note ...