Lori remarried, but neither she nor Stamos have any qualms telling journalists exactly how they feel about each other. Stamos declared in a recent interview that Loughlin was "the one that got away," causing her to momentarily cast all knowledge of her husband into the comfortable oblivion of selective memory. Apparently, the formidable combination of mullet and leather vest is simply too powerful to be denied.
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If a bunch of TV producers locked them together in a Real World townhouse, how long would it take for them to drown each other in a hot tub full of consensual nudity (giving Cameron Bure something else to freak the hell out about)? We're looking at maybe two or three episodes of tension before Loughlin files for divorce via extramarital sex on broadcast television.

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There's Gotta Be Some Resentment Between Saget and Coulier
As struggling comic Joey Gladstone, Coulier was supposed to be the funny one, while Saget's neurotic germophobe was supposed to be the straight man (although, in eight years of television, neither managed to be legitimately funny). What fans of the show didn't know at the time was that Saget is one of the filthiest stand-up comedians in history, which raises the question "Why was he chosen to star in a family sitcom?" And in the years following Full House, Saget's become somewhat famous for his propensity to curse all of the time for no reason.