Appropriately, raising the show about fantasy espionage and murder to this seemingly untouchable position can only mean that it's about to get cut down in its prime, thanks to a series of inescapable problems looming on the horizon like a shambling horde of White Walkers that both George R.R. Martin and HBO seem as content to ignore as the people of King's Landing.
4 They're Running Out of Books
Seasons 3 and 4 of Game of Thrones were primarily a split-up version of A Storm of Swords, Martin's third book in the A Song of Ice and Fire series. (Seasons 1 and 2 knocked out the first two books.) The end of Season 4 also covered some material from the fourth book, A Feast for Crows. Now, although A Song of Ice and Fire is projected to eventually be seven books long, only five of those books have been written, and the show has already covered four of them. That means we have roughly one and a half more books of story left (two stretched-out seasons at most) before all of America unanimously turns to Martin and politely coughs. When questioned about this in interviews, both Martin and the show's producers have been breezily optimistic, because two seasons of show should be plenty of time for Martin to fart out a sixth book, right?
Actually, it took Martin six goddamn years to write the last one, and that came out in 2011. He spent five years apiece on each previous novel in the series, meaning that at best the sixth book will be out sometime in 2016, and at worst it will be out sometime in "Who the hell knows?" which was literally the projected release date Martin gave back in 2011. Even he doesn't know when the fuck that book is going to come out.
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He was 19 when the first book was released.
Even if by some miracle (granted by the enchanted amulet he no doubt keeps hidden beneath his longshoreman's cap) Martin manages to heave out the sixth book in time for a 2016 photo finish, that still doesn't factor in the yearlong production schedule that each season of Game of Thrones requires. That means the soonest we'd see Season 6 would be 2018, and then we'd have to wait another five fucking years for Martin to put out the seventh book, putting the series finale somewhere in the realm of 2023.