I figure I'll start with this in case the clumsy eyes of some people who don't know how to skip spoilers stumble on down this far. The very first thing anyone finds out about this show is that the main character, Frank Underwood, talks to the camera a lot. Breaking the ol' fourth wall, if you will. This device can sometimes be daring and sometimes be what we in the business refer to as "too precious by half." Personally, I would say House of Cards is leaning heavily toward preciousness in this case.
DISCLAIMER: May not be actual dialogue from the show.
But this is a really easy lemon to turn into lemonade. These fourth wall hijinks can be turned from an overly cute narrative device into a subtle chronicle of a man losing his mind with just a few camera angle changes.
I'd suggest ramping it up slowly, maybe for the first one or even two episodes just doing the regular "talking to the camera" thing, no change. Then maybe right at the end of the second episode, while Frank is monologing at the audience, switch to a slightly different camera angle as he keeps yakking at what you can now see is a blank wall.