Misfits Of Science concerned four superpowered youths and their non-superpowered leader, which is kind of like hiring a penis-less gorilla to organize your Olympic All-Gorilla Dick-Measuring Contest. The show is not very good, and the not-very-good aspects include Courteney Cox, fresh off of her role as Mortified Dancing Woman in Bruce Springsteen's "Dancing In The Dark" video. Courteney had improved by the time she starred in Misfits Of Silence. For one, she dances way less. But her line delivery does not indicate that she would one day go on to play the second-best Friends character. (FOR THE RECORD AND FROM BEST TO WORST: Rachel, Monica, Chandler, Phoebe, Joey, Ross.)
If there had never been any proof of something like this working, I would doom Misfits Of Science to the crypt of questionable science fiction ideas -- a crypt that includes things like Battlefield Earth and two of my three pieces of Jurassic Park fanfiction. And to be fair, it is harder to pull this off than it would be with a show that's just adapting a comic universe. If you're making something based on a Marvel idea, you have a blueprint of what the relationships and storylines might be. But it can be done. The first season of Heroes pulled off a TV-only superhero series nicely. The first season of a one-season show. There was only one season of Heroes. Season 2 is fake news.
A modern Misfits Of Science series, updated to be a little more dramatic but still retaining the comedy, would be great in 2017, especially since we're steadily mastering the formula of these fantastical concept shows. Plus, improved special effects will mean that a 2017 Misfits Of Science wouldn't look like it was filmed by mistake. However, considering that it's 2017, it will probably get some vague tech-company-sounding title, like Changed or just Misfits (which would piss off fans of British TV, but few others would care). Courteney Cox can still be in it, though, as like the head of the Humanidyne Institute that researches the superheroes. And in Episode 1, she can turn to the camera and say, "They're not freaks. They're misfits ... OF SCIENCE." But on the inside, she'll be crying.