Even if you stay confined to America, driving around Los Angeles is nothing like driving around Boston or Seattle or anywhere else. The cars are speaking different languages to each other. In Seattle, a turn signal means "I wanted to turn back there, but it was a one-way street." In Boston, it means "I forgot my blinker is on." And in LA, it means "I'm new here, please pass me." Roads are different, too: In D.C., some lanes will change direction at different parts of the day, like they're a staircase at fucking Hogwarts.
There's a reason those things vanished after the first movie.
So let's say you want to take the easy way out and rely on public transit. Ha. This means you either make friends with a local or learn a complex form of math unique to that city and not taught in any schools. I visited New York City with native New Yorker Alex Schmidt, and the whole time I felt like I was following Gandalf through Moria (minus the part where Gandalf got lost). I'd say "let's visit Central Park" and he'd wave his subway card three times and bam, we were in the forest. I didn't plan on trusting Schmidt with my life that weekend, but I did, so consider this me officially vouching for his trustworthiness.
But once you leave America, that's when things get really confusing. Not only do people in other countries drive on the wrong side of the road (how fucking hard would it be to standardize that, Earth?) but they also navigate roads totally differently. What's the fastest way to the peak of a volcano? If you said "in a minivan, far more quickly than seems safe," then you must be from Trinidad or anywhere in the Eastern Caribbean. And I'm sure you've seen this video of an Iranian "intersection."