As the title implies, Vampire: The Masquerade is about werewolves. There's enough backstory to make Anne Rice look like Stephenie Meyer, but basically you play as a modern L.A. vamp caught up in the politicking of the creatures of the night.
At one point, you're given a quest called "Pimpin' For Romero." Romero is a human who serves vampires by fighting zombies who keep popping up at a cemetery. He asks you to cover his shift while he visits a prostitute, because, as The Walking Dead taught us, getting your dick wet always takes priority over battling shambling harbingers of the apocalypse.
Activision "But you know what else ain't pretty? My testicles right now."
As a male vampire, you have two options. You can agree to help suppress the zombie uprising and sate Romero's libido, which launches you into one of the hardest and most frustrating battles in the game. Or you can fetch a prostitute, convince her that there's nothing dangerous about following a creepy stranger to a dilapidated shack in a graveyard in the dead of night, and let Romero enjoy some female company in the comfort of his own zombie-brain-splattered home.
But if you're playing as a lady vampire, you can bypass this whole dilemma with your vagina. What woman wouldn't want to pimp herself out for a few experience points and some free shotgun shells? Well, first, there's the fact that Masquerade's vampires don't enjoy sex or produce any liquid other than blood, so brace yourself for some very dry necrophilia. To make matters worse, Romero talks like he's responsible for creating half the angry corpses in his graveyard. First, he calls you a striking piece of ass after having known you for all of five minutes, and then he asks if you're interested in the "old naughty tango." Try to restrain yourselves, ladies.
Activision To be fair, Mary Magdalene used the same line on Jesus.