If the truth was actually known, it is probably censorship more than appetite that caused Wile E. Coyote's enmity for the Road Runner.
The Motion Picture Production Code, which is also referred to as The Hays Code (for an early censor) , contained extensive lists on what could not be done in a Motion Picture. The Motion Picture Production Code had two seperate sections dealing with speech. One section was based on common 'vulgarity' and another section was referring to 'blasphemy.' The power of the Hays Code was such that in order to have any motion picture shown, compliance was neccessary,. The Hays Code was in effect roughly from 1934 - 1967. The First Road Runner / Wile E. Coyote Cartoon was in 1949 and the last of the original series was in 1966.
Thus, the Hays Code and the Road Runner cartoons directly coincided with each other.
It was also common practice during this period to have 'curse words' 'bleeped out' if they happened to be part of a live clip that made it on to television.
Now, isn't it rather curious that the exact same sound used for the subjugation of foul languange during the exact same period ini which the Hays Code was in full effect just happens to be the exact same languange of the Road Runner?
O.K., allow us to conjecture for just a minute here. This foul mouthed little bird sends us to certain doom hurtling down a canyon to a certain crash and lays out a hearty variation of an F-Bomb every time he does it?
You are absolutely right that this bird has an atomic anal suppository coming in his very near future.
In the stand up routine Bill Cosby Himself. Cos talked about how talking in front of children made you sound like an idiot. This would be because you did not want to curse. It is all a string of "What the..." "I'll get your...." "Get Out of Here!!!" Likewise, the Coyote also looks like a blasted idiot for having all the finances in the world to buy bombs as well as every other contraption and not a cent for dinner. That is until you factor in years of cursing rude disrespectful behavior by one foul mouthed little bird.