4Dr. Lisa Cuddy, Dean of Medicine and Chief Hospital Administrator (House)
As Dean of Medicine, you have a tremendous burden. You must earn and maintain the respect of patients and egomaniacal doctors alike while asserting an air of leadership the moment you walk in the room. Significantly less important to the job is asserting that you have huge boobs.
For an eminently successful and intelligent medical professional, Dr. Lisa Cuddy has certainly amassed a number of self-sabotaging behaviors. We suspect all that stems from her frustration at having earned everything that she has received rather than sleeping her way to the top. This type of frustration can manifest itself in many ways, a soft-spot for inveterate misogynists for example.
None of these side-effects are more unfortunate than her desperate insistence on flaunting her well-supported sweater kittens at every opportunity. Working in her office, making her rounds, evaluating a patient: it doesn't seem to matter who she is distracting, or how much she risks undermining her authority.
Her cleavage is probably responsible for more off-screen deaths in the House universe than cancer.
3Melinda the Ghost Whisperer (Ghost Whisperer)
You can't go to school to be a ghost whisperer: it's in the genes. The kid from The Sixth Sense and Melinda the "ghost whisperer" both have the gift of seeing freaky dead people and being able to talk to them. Melinda, though, seems to have doubled up in the "gift" department.
Unlike the kid from the Sixth Sense, Melinda does not spend her time being scared shitless, huddled under a mountain of blankets and dressed in conventional sleeping attire. Neither does she go with the Shaggy technique of cowering inside a suit of armor with a talking dog and self-medicating with a huge bag of weed.
No, that would hinder Melinda's work as a ghost whisperer and would deprive the world of her spectacular rack.
Does it seem all that strange that Melinda is constantly encountering spirits of the hostile variety? After all, she seems intent on reminding them that they have passed from the world of flesh and that there are no boobies in the afterlife.