13Slippy Toad from Star Fox 64
This toad pilot and mechanical genius is a valued member of the Star Fox team. That is, until he opens his mouth, engages in combat, or pretty much does anything.
Why he annoyed us:
You'd think that a toad flying a jet fighter in space would be nothing short of awesome. You'd be wrong. During every mission, Slippy quickly makes himself the most hated member of the Star Fox team by using his high-pitched voice to shout random, useless advice. During combat, his idea of dogfighting seems to be getting trapped by the enemy and bugging Fox to save him.
We're assured during the game that his mechanical expertise makes him invaluable, which must be the only reason he isn't blown out of the sky by friendly fire five seconds after takeoff.
12Ashley Graham from Resident Evil 4
Resident Evil 4 sends you off to rescue Ashley, the president's daughter. Once you find her, keeping her alive becomes a tedious, full-time job for the rest of the game.
Why she annoyed us:
When will game developers learn that no one enjoys protecting the weak and defenseless? Or even worse, controlling them?
Like Resident Evil 2's Sherry Birkin before her, Ashley's special abilities include being difficult, slowing you down, and making the game less fun. It gets to the point that when Ashley gets recaptured, it's like a weight has been lifted. You can go back to slaughtering mutated Spanish villagers unencumbered. The whole second half of the game revolves around saving Ashley from a parasite implanted in her body that would turn her into an inhuman horror. How many of us were hoping the parasite would take over so we would have an excuse to bombard her with incendiary grenades?